Pope Sixtus IV commissioned the Sistine Chapel's wall frescoes in the early 1480s, gathering some of the most sought after painters in Italy, Perugino, Sandro Botticelli, Domenico Ghirlandaio and Cosimo Rosselli among them, for a single coordinated cycle setting the life of Moses against the life of Christ across the chapel's two long walls. Delivery of the Keys occupies the most prominent position of all, the center of the north wall, exactly where a viewer's eye settles first on entering the chapel.
The timing is not thought to be accidental. Sixtus IV's papacy came a few decades after conciliarist theologians had argued that a general council of bishops, not the pope alone, held final authority in the church, and after decades in which rival claimants had at times occupied the papal throne at once. Art historians commonly read Delivery of the Keys as part of an answer to that argument, an assertion that Christ's own authority passed to Peter alone, and through Peter to every pope since, painted onto the walls of the very room where the College of Cardinals would gather to elect Sixtus's own successors.
Perugino reinforced the point architecturally. The temple filling the fresco's background is not the historical Temple of Jerusalem but a Renaissance domed octagon, flanked by two triumphal arches modelled on the Arch of Constantine in Rome, the emperor who first gave the church legal standing. The visual line the fresco draws from Roman imperial authority to papal authority is as deliberate as the keys themselves.