Pikuach nefesh, the preservation of human life, is the principle that saving a life overrides almost the whole of Jewish law. The Talmud derives it from Leviticus 18:5, "you shall keep my statutes and my ordinances, which if a person does, he shall live by them", read as: live by them, and not die by them (Yoma 85b). Where life is at stake the Sabbath may be violated, fasts broken, and forbidden food eaten.
The standard is deliberately low and the tradition is emphatic about it. The threshold is not certainty of danger but reasonable possibility; one acts on doubt, and acts at once rather than pausing to seek a ruling. The law states that the prompt actor is praiseworthy, and that one who delays to ask whether it is permitted has done something blameworthy. The Mishnah's declaration that whoever saves a single life is regarded as having saved an entire world (Sanhedrin 4:5) is the principle's best-known expression.
Its applications are continuous and concrete: summoning medical help and travelling on the Sabbath, feeding the sick and women in childbirth on the Day of Atonement, and, in a much-cited nineteenth-century instance, Israel Salanter's conduct during a cholera epidemic in Vilna, where he is reported to have eaten publicly on Yom Kippur to establish that the ill and weakened must do so. Modern authorities have applied it to vaccination, organ donation, and public health measures, and during the COVID-19 pandemic rabbinic authorities across the denominations invoked it in suspending public worship.
There are limits, and they are few. The three cardinal prohibitions, idolatry, murder, and the forbidden sexual relations, are not set aside; one is required to accept death rather than transgress them (Sanhedrin 74a). Even here the reasoning is instructive: the rule against murder to save oneself rests on the argument that one cannot know whose blood is redder, which is a statement about the equality of lives rather than about the sanctity of a rule. In periods of decreed persecution aimed at compelling public apostasy, the rabbis extended the requirement of martyrdom beyond the three, a ruling shaped by the medieval experience of forced conversion.