When the argument between the priest Arius and his bishop over the status of the Son spread across the eastern provinces, Constantine treated it as a threat to public order and did what a Roman emperor did with disorder: he summoned a meeting. The council that assembled at Nicaea in 325 brought bishops from across the empire, travelling on the imperial post at public expense, and the emperor attended in person, opened the proceedings and pressed hard for a form of words everyone could sign.
The creed the council produced described the Son as of one substance with the Father. The Greek word, homoousios, had no scriptural warrant, and a number of bishops were uncomfortable with it for exactly that reason. It settled far less than it appeared to. Arian and semi-Arian positions held imperial favour repeatedly over the next half century, Athanasius was exiled five times, and Constantine himself recalled Arius from banishment and was baptised on his deathbed by Eusebius of Nicomedia, a bishop of the party the council had condemned.
The lasting result was not the doctrine but the machinery. From 325 onward an emperor could convoke a council, underwrite its travel, sit in it, and expect its decisions to carry the force of imperial law, while a bishop who lost the argument could be removed by an administrative order. Every later dispute about the relation of church and state in the Christian East and West is arguing with the arrangement Constantine improvised.