It is easy to file Paracelsus as a magical thinker with lucky guesses. The more accurate account is that his metaphysics and his method were entangled, and both produced results.
He replaced the four humours with the tria prima, salt, sulphur and mercury, understood as principles of body, soul and spirit as much as substances, and treated disease as an external agent attacking a specific organ rather than an internal imbalance of fluids. That is a genuine shift toward disease as a thing with a cause and a seat. He introduced mineral and chemical remedies into a pharmacy that had been almost entirely herbal, and is the founder of what became iatrochemistry and eventually pharmacology. He described the occupational lung disease of miners as a disease of miners rather than a punishment, which is close to the beginning of occupational medicine. He named zinc.
The line most quoted from him is also the soundest: all things are poison and nothing is without poison, and only the dose makes a thing not a poison. That is the dose-response principle, and it is the foundation of toxicology.
The rest of the system is not detachable from this and should not be quietly dropped. He held to the doctrine of signatures, that a plant's form advertises its use; to the archeus, an inner alchemist governing digestion and growth; to a cosmos in which the human being is a compressed image of the whole; and to a populated nature of elemental beings, his treatise on nymphs, sylphs, pygmies and salamanders is the source from which the four-element scheme of elementals entered Western occultism and, through it, most modern fantasy. Walter Pagel's and Charles Webster's studies are the standard treatments, and both insist on the same point: the medicine and the magic were one project, and separating out the parts that worked is our operation, not his.