The Left Angle Cross of Separation is named for Gate 35 and Gate 5. Human Design reads Gate 35, from Hexagram 35, Progress, as a hunger for progress and for the feeling only a new experience can supply, and Gate 5, from Hexagram 5, Waiting, as a fixed inner rhythm governing eating, sleeping and work. It belongs to the Left Angle family, read as transpersonal, a direction practitioners describe as answering less to personal choice than to what circumstance hands the individual, which is where the cross's name of separation is read from.
Its design half is Gate 22 and Gate 47. Gate 22 sits in the Solar Plexus and is read as a social grace that flows or withdraws with the emotional wave rather than on demand; elsewhere it pairs with Gate 12 in the channel of Openness. Gate 47 sits in the Ajna and is read as a mind working over confusion, sometimes for a long time, until sense finally arrives of itself; it pairs with Gate 64 in the channel of Abstraction.
So the cross joins restless appetite for new experience, Gate 35, to a fixed bodily rhythm, Gate 5, on its surface, while beneath it emotional grace answers to a mind still working toward its own realization. The hexagrams are ancient; grouping them into one transpersonal cross is the modern system's own construction, dated to 1987.