This profile uses the same two line positions as another profile in the set, in the opposite order, and that fact says something about how the scheme is built.
Ordered, not unordered
Human Design's twelve profiles are ordered pairs. The first number is taken from one part of the calculated chart and the second from another, so four and one is a different profile from one and four even though the same two lines are involved. Six of the twelve profiles are the reverses of the other six.
That is why the count is twelve rather than six: the twelve are the ordered pairs whose lines are separated by two or by three positions, and each such separation supplies a pair in each direction.
What the commentaries say about these positions
The fourth line is the bottom of the upper trigram of a hexagram, next below the ruling position, and classical Yijing commentary reads it as anxious and exposed. The first line is the bottom of the whole figure, the start of the situation, and is read as obscure and not yet in a position to act.
Commentary also holds these two to correspond, one of three such pairs in a hexagram.
The modern layer
The role names on the six lines, and the reading of a profile as a personality, are Ra Uru Hu's, published in 1987, and are not the commentarial readings above.