Among the distinctive features of Human Design is a specific physical mechanism, which Ra Uru Hu proposed and which most other systems of this kind do not attempt.
The claim is that neutrinos are the carrier. Neutrinos are produced in enormous quantities by nuclear fusion in stars, pass through matter almost unimpeded, and stream through every human body continuously. Human Design holds that these particles carry information from the bodies that emit them, and that as they pass through a person they imprint that information, so that the planetary positions at particular moments become fixed in the individual.
One part of this is worth reporting accurately because it is often garbled in both directions. Ra Uru Hu maintained from 1987 that neutrinos have mass, at a time when the standard model treated them as massless and the question was genuinely open in physics. In 1998 the Super-Kamiokande experiment demonstrated neutrino oscillation, which implies non-zero mass, and the result was recognised with a share of the 2015 Nobel Prize in Physics. Practitioners cite this as a confirmed prediction.
What the physics does not supply is the rest of the claim. That neutrinos have a small mass is established. That they carry structured information about the stars they came from, that this information is imprinted on biological tissue, and that the imprint corresponds to hexagram positions on a zodiacal wheel, are not established and are not the subject of any research programme. Neutrinos interact with matter so weakly that detecting them at all requires enormous instruments, which is the specific difficulty the informational claim would need to address.
The system holds it. It is stated here as what the system holds.