The Gene Keys are new, and the system says so, which puts it in a better position than several older-seeming disciplines on this list.
Richard Rudd, an English writer and teacher, studied Human Design and worked as an analyst within it before developing his own material; the Gene Keys use the same birth calculation and the same sixty-four-fold I Ching base, and Rudd has described the relationship openly. The book appeared in 2009, and the Golden Path programme and the surrounding organisation followed.
The materials it draws on are correspondingly identifiable. The I Ching supplies the sixty-four archetypes, though the Gene Keys attach their own three-frequency scheme rather than the hexagram texts. Kabbalah and the chakras appear through the Human Design inheritance. Astrology supplies the calculation. Sanskrit vocabulary, siddhi, and the language of awakening, supplies the register of the highest frequency. And the language of genetics is used as sustained metaphor: the sixty-four keys are mapped onto the sixty-four codons of the genetic code, a correspondence which is arithmetically exact and which the system uses poetically rather than as a biological claim.
That last point deserves to be stated clearly, because it is the place where the system could most easily be misread. The genetic code really does have sixty-four codons, and the I Ching really does have sixty-four hexagrams. There is no established relation between them. The correspondence is a numerical coincidence used as an image, and the Gene Keys literature generally presents it as such rather than asserting that contemplating a key alters gene expression.
No controlled study of the system exists, and its own framing, slow contemplation, judged by the practitioner over years, does not readily admit of one. Practitioners describe the value as insight rather than information.